This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miller, P. L. Search for Related Content PubMed PubMed Citation Articles by Miller, P. L.

Opportunities at the Intersection of Bioinformatics and Health Informatics

A Case Study

Affiliation of the author: Yale University, New Haven, Connecticut.

Correspondence and reprints: Perry L. Miller, MD, PhD, Center for Medical Informatics, Yale University School of Medicine, P.O. Box 208009, New Haven, CT 06520-8009; e-mail: perry.miller{at}yale.edu.

Abstract This paper provides a "viewpoint discussion" based on a presentation made to the 2000 Symposium of the American College of Medical Informatics. It discusses potential opportunities for researchers in health informatics to become involved in the rapidly growing field of bioinformatics, using the activities of the Yale Center for Medical Informatics as a case study. One set of opportunities occurs where bioinformatics research itself intersects with the clinical world. Examples include the correlations between individual genetic variation with clinical risk factors, disease presentation, and differential response to treatment; and the implications of including genetic test results in the patient record, which raises clinical decision support issues as well as legal and ethical issues. A second set of opportunities occurs where bioinformatics research can benefit from the technologic expertise and approaches that informaticians have used extensively in the clinical arena. Examples include database organization and knowledge representation, data mining, and modeling and simulation. Microarray technology is discussed as a specific potential area for collaboration. Related questions concern how best to establish collaborations with bioscientists so that the interests and needs of both sets of researchers can be met in a synergistic fashion, and the most appropriate home for bioinformatics in an academic medical center.

This article has been cited by other articles:

				E. M. van Mulligen, M. Cases, K. Hettne, E. Molero, M. Weeber, K. A. Robertson, B. Oliva, G. de la Calle, and V. Maojo Training Multidisciplinary Biomedical Informatics Students: Three Years of Experience J. Am. Med. Inform. Assoc., March 1, 2008; 15(2): 246 - 254. [Abstract] [Full Text] [PDF]

				V. Maojo and C. A. Kulikowski Bioinformatics and Medical Informatics: Collaborations on the Road to Genomic Medicine? J. Am. Med. Inform. Assoc., November 1, 2003; 10(6): 515 - 522. [Abstract] [Full Text] [PDF]

				W. W. Stead The Challenge of Bridging Between Disciplines J. Am. Med. Inform. Assoc., January 1, 2001; 8(1): 105 - 105. [Full Text]