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First published July 23, 2002 as JAMIA PrePrint; doi:10.1197/jamia.M1103
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Journal of the American Medical Informatics Association 9:461-471 (2002)
© 2002 American Medical Informatics Association

Model Formulation

Modeling and Simulation of Pathways in Menopause

Dimitra Tsavachidou, MD and Michael N. Liebman, PhD

Affiliations of the authors: Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania.

Correspondence and reprints: Michael N. Liebman, PhD, 511 BRBII/III, 421 Curie Boulevard, Philadelphia, PA 19104; e-mail: <liebmanm{at}mail.med.upenn.edu>.

The analytical representation and simulation of complex molecular pathways can contribute to understanding and evaluating physiological as well as pathological processes. We are interested in modeling the processes of menopause to stratify women in terms of the genotypic and environmental components and their implications for development of individualized risk of postmenopausal disorders, e.g., breast and ovarian cancer, cardiovascular disease, and osteoporosis. We have initiated this study using the UltraSAN package to analyze the pathway associated with estrogen production. This model incorporates detailed information about the hormone factors affecting estrogen production, and the simulations carried out are based on published experimental data corresponding to hormone levels during the course of the normal female reproductive cycle. The agreement between the experimental data and the simulation is typically less than 2 ng/ml or 2 pg/ml respectively for progesterone and estradiol output. This approach further permits inclusion of information about an SNP observed in the gene coding for the enzyme aromatase as a model to study the impact of reduced enzymatic activity on hormone levels.




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