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Submitted on November 6, 2001
Accepted on August 9, 2002
Affiliation of the authors: 1 Department of Anesthesiology, University of Washington, Seattle, WA; 2 Department of Statistics, University of Washington, Seattle, WA; 3 Department of Medicine, University of Washington, Seattle, WA; 4 Department of Health Sciences Libraries, University of Washington, Seattle, WA; 5 Department of Pharmacy, University of Washington, Seattle, WA; 6 Talaria Inc, Seattle, WA; 7 Department of Psychology, University of Washington, Seattle, WA
* To whom correspondence should be addressed.
Failure to adhere to complex antiretroviral regimens can lead to resistance and treatment failure among HIV-positive persons. In this study of the feasibility of an automated two-way messaging system to improve adherence, participants received multiple short daily messages designed to remind, educate, encourage adherence, and solicit responses concerning side effects and self-reported adherence. Twenty-five participants remained in the study for a median of 208 days, receiving 17,440 messages and replying to 14,677 (84%). Participants reported missing one or more doses on 36% of 743 queries and reported medication side effects on 26% of 729 queries. Participants expressed high satisfaction with the messaging system and reported it helped with medication adherence. The study suggests it is feasible to use an automated wireless two-way messaging system to communicate with HIV-positive patients over an extended period of time.
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