help button home button JAMIA Bigger figures
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
First published January 28, 2003 as JAMIA PrePrint; doi:10.1197/jamia.M1193
Journal of the American Medical Informatics Association 2003;10(3):271-280
© 2003 American Medical Informatics Association

A more recent version of this article appeared on May 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
M1193v1
10/3/271    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duclos-Cartolano, C.
Right arrow Articles by Venot, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duclos-Cartolano, C.
Right arrow Articles by Venot, A.

Submitted on August 1, 2002
Accepted on December 16, 2002

Building and evaluation of a structured representation of pharmacokinetics information presented in SPCs: from existing conceptual views of pharmacokinetics associated with natural language processing to object-oriented design

Catherine Duclos-Cartolano PharmD1 and Alain Venot MD, PhD1*

Affiliation of the authors: 1 Laboratoire d'Informatique Medicale et de Bioinformatique (LIM&BIO), UFR Sante, Medecine, Biologie Humaine, Universite Paris 13, Bobigny, France

* To whom correspondence should be addressed.

Objective Develop a detailed representation of pharmacokinetics (PK), derived from the information in Summaries of Product Characteristics (SPCs), for use in computerized systems to help practitioners in pharmaco-therapeutic reasoning.

Methods Available knowledge about PK was studied to identify main PK concepts and organize them in a preliminary generic model. The information from 1,950 PK SPC- texts in the French language was studied using a morpho-syntactic analyzer. It produced a list of candidate terms (CTs) from which those describing main PK concepts were selected. The contexts in which they occurred were explored to discover co-occurring CTs. The regrouping according to CT semantic types led to a detailed object-oriented model of PK. The model was evaluated. A random sample of 100 PK texts structured according to the model was judged for completeness and semantic accuracy by 8 experts who were blinded to other experts' responses.

Results The PK text file contained about 300,000 words, and the morpho-syntactic analysis extracted 17,520 different CTs. The context of 592 CTs was studied and used to deduce the PK model. It consists of four entities: the information about the real PK process, the experimental protocol, the mathematical modeling, and the influence of factors causing variation. Experts judged that the PK model represented the information in 100 sample PK texts completely in 89% of cases and nearly completely in the other 11%. There was no distortion of meaning in 98% of cases and little distortion in the remainder.

Conclusion The PK model seems to be applicable to all SPCs and can be used to retranscribe legal information from PK sections of SPCs into structured databases.




This article has been cited by other articles:


Home page
 BioinformaticsHome page
S. Xirasagar, S. F. Gustafson, C.-C. Huang, Q. Pan, J. Fostel, P. Boyer, B. A. Merrick, K. B. Tomer, D. D. Chan, K. J. Yost III, et al.
Chemical effects in biological systems (CEBS) object model for toxicology data, SysTox-OM: design and application
Bioinformatics, April 1, 2006; 22(7): 874 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Med. Inform. Assoc.Home page
C. Duclos, G. L. Cartolano, M. Ghez, and A. Venot
Structured Representation of the Pharmacodynamics Section of the Summary of Product Characteristics for Antibiotics: Application for Automated Extraction and Visualization of Their Antimicrobial Activity Spectra
J. Am. Med. Inform. Assoc., July 1, 2004; 11(4): 285 - 293.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 1994 by the American Medical Informatics Association.