Both teachers and students benefit from an interactive classroom. The teacher receives valuable input about effectiveness, student interest and comprehension, while student participation, active learning and enjoyment of the class is enhanced. The use of existing audience response systems, allowing anonymous linking of teachers and students in the classroom, has been limited by cost and deployment. These limitations can be circumvented, however, by use of Personal Digital Assistants (PDAs), which are cheaper and widely used by students. In this study, we equipped a summer histology class of twelve students with PDAs and wireless Bluetooth cards to allow access to a central server. Teachers displayed questions in multiple-choice format as a webpage on the server and students responded via their PDA, a process referred to as polling. Responses were immediately compiled, analyzed, and displayed. End-of-class survey results indicated that students were enthusiastic about the polling tool. The surveys also provided technical feedback that will be valuable in streamlining future trials.