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First published February 28, 2007 as JAMIA PrePrint; doi:10.1197/jamia.M2177
Journal of the American Medical Informatics Association 2007;14(3):264-268
© 2007 American Medical Informatics Association

A more recent version of this article appeared on May 1, 2007
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Submitted on June 12, 2006
Accepted on January 24, 2007

Evaluation of an online platform for cancer patient self-reporting of chemotherapy toxicities

Ethan Basch MD, MSc1*, David Artz MD, MBA1, John Speakman2, Alexia Iasonos PhD2, Kevin Shannon3, Kai Lin4, Charmaine Pun3, Henry Yong3, Paul Fearn5, Allison Barz2, Howard I. Scher MD6, Mary McCabe RN, PhD7, and Deborah Schrag MD, MPH1

Affiliation of the authors: 1 Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY ; 2 Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY ; 3 Department of Information Services, Memorial Sloan-Kettering Cancer Center, New York, NY ; 4 Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY; 5 Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY; 6 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY ; 7 Department of Physician-in-Chief’s Office, Memorial Sloan- Kettering Cancer Center, New York, NY

* To whom correspondence should be addressed.

The current mechanism for monitoring toxicity symptoms in cancer trials depends on a complex paper-based process. Electronic collection of patient-reported outcomes (PROs) may be more efficient and accurate. An online PRO platform was created including a simple data entry interface, real-time report generation, and an alert system to email clinicians when patients self-report serious toxicities. Feasibility assessment involving 180 chemotherapy patients demonstrated high levels of use at up to 40 follow-up clinic visits per patient over 16 months (85% of patients at any given visit), with high levels of patient and clinician acceptance and satisfaction (>95%). Alerts were used as the basis for delayed chemotherapy treatments, dose modifications, and scheduling changes. These results demonstrate that online patient-reporting is a feasible strategy for chemotherapy toxicity symptom monitoring, and may improve safety and satisfaction with care. Ongoing multi-center research will evaluate the impact of this approach on clinical and administrative outcomes.




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Should Patient-Reported Outcomes Be Mandatory for Toxicity Reporting in Cancer Clinical Trials?
J. Clin. Oncol., December 1, 2007; 25(34): 5345 - 5347.
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A. Trotti, A. D. Colevas, A. Setser, and E. Basch
Patient-Reported Outcomes and the Evolution of Adverse Event Reporting in Oncology
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